Capar M, Kosić-Andrasević V, Popić G, Raguz L, Mahuĺja-Stamenković V, Zuzek A, Dujmović A, Milevoj-Razem M, Ljutić S
Department of Pediatrics, Medical Center, Pula, Croatia.
Acta Med Croatica. 1995;49(4-5):161-4.
A prospective study was performed to determine whether the risk factor for hepatitis B, proposed by Centers for Disease Control (CDC), USA, are reliable predictors for the hepatitis B surface antigen (HBsAg) carrier state in an obstetric population. In the period between January 1, 1991 and December 31, 1992, all pregnant women from geographically defined areas of the Istrian and Rijeka districts were routinely screened for hepatitis B surface antigen (HBsAg). Among 10,627 pregnant women, 107 (1%) HBsAg positive cases were registered. History risk factors recommended by CDC were recorded in 46 (43%) out of 107 HBsAg positive women. The other 61 subjects had no recognizable risk factors. The screening of pregnant women for HBsAg only on the basis of the CDC recommended history guidelines, would have left 57% of our HBsAg positive mothers undetected and therefore their children unvaccinated against hepatitis B infection. Our results confirmed the need and value of the new CDC recommendations about routine prenatal screening of all pregnant women for HBsAg until hepatitis B vaccine is included in the scheme of compulsory vaccination of all newborns.
开展了一项前瞻性研究，以确定美国疾病控制中心（CDC）提出的乙肝风险因素是否是产科人群中乙肝表面抗原（HBsAg）携带者状态的可靠预测指标。在1991年1月1日至1992年12月31日期间，对伊斯特拉和里耶卡地区地理界定区域内的所有孕妇进行了乙肝表面抗原（HBsAg）的常规筛查。在10627名孕妇中，登记了107例（1%）HBsAg阳性病例。在107例HBsAg阳性女性中，46例（43%）记录了CDC推荐的病史风险因素。其他61名受试者没有可识别的风险因素。仅根据CDC推荐的病史指南对孕妇进行HBsAg筛查，会使我们57%的HBsAg阳性母亲未被检测出来，因此她们的孩子未接种乙肝感染疫苗。我们的结果证实了CDC关于对所有孕妇进行HBsAg常规产前筛查的新建议的必要性和价值，直到乙肝疫苗被纳入所有新生儿的强制疫苗接种计划中。
