Barĭć I, Reiner-Banovac Z, Verona E, Sabioncello A
University Department of Pediatrics, Sestre Milosrdnice University Hospital, Zagreb, Croatia.
Acta Med Croatica. 1995;49(4-5):177-80.
Dermatophagoides pteronyssinus (DP) is, for unknown reasons, the commonest cause of asthma attacks in children suffering from reaginic bronchial asthma. The underlying immune disorder is also unclear. The authors analyzed phagocytosis (ingestion), digestion and antibody-dependent cellular cytotoxicity (ADCC) of peripheral blood leukocytes in 20 asthmatic children hypersensitive to DP, aged 2 to 14 years. The tests were performed while the children were entirely asymptomatic and under no therapy. The aim was to determine the possible difference in comparison to healthy children and to assess the correlation of these results with the total serum IgE level, DP-specific IgE and duration of the disease. Ingestion in asthmatics did not differ significantly from that in controls, while digestion and ADCC were significantly (P < 0.01) lower in asthmatics. This phenomenon could contribute to their difficulties in the elimination of allergens, immune complexes and microbial, particularly viral antigens, making them more susceptible to allergic reaction and infections. No significant correlation to the total serum IgE level, DP-specific IgE and duration of the disease was found.
出于不明原因，屋尘螨是患反应性支气管哮喘儿童哮喘发作最常见的诱因。其潜在的免疫紊乱情况也不清楚。作者分析了20名年龄在2至14岁、对屋尘螨过敏的哮喘儿童外周血白细胞的吞噬作用（摄取）、消化作用以及抗体依赖的细胞毒性作用（ADCC）。检测是在这些儿童完全无症状且未接受任何治疗的情况下进行的。目的是确定与健康儿童相比可能存在的差异，并评估这些结果与血清总IgE水平、屋尘螨特异性IgE以及病程的相关性。哮喘儿童的摄取作用与对照组相比无显著差异，而哮喘儿童的消化作用和ADCC则显著更低（P < 0.01）。这种现象可能导致他们在清除过敏原、免疫复合物以及微生物（尤其是病毒抗原）方面存在困难，从而使他们更容易发生过敏反应和感染。未发现与血清总IgE水平、屋尘螨特异性IgE以及病程有显著相关性。
