Ridgeway A L, Warner G S, Phillips P, Forshag M S, McGiffin D C, Harden J W, Harris R H, Benjamin W H, Zorn G L, Dunlap N E
Department of Medicine, University of Alabama at Birmingham, USA.
Am J Respir Crit Care Med. 1996 Mar;153(3):1166-8. doi: 10.1164/ajrccm.153.3.8630561.
Recipients of organ transplants are at increased risk for infection both because of immunosuppression and because of the transfer of microbes through the donor organs. We report two cases of M. tuberculosis disease in recipients of single lung transplants who shared a common donor. Both recipients developed pulmonary tuberculosis, one having fever and pulmonary infiltrates and the other having subclinical disease with M. tuberculosis organisms being recovered from bronchoalveolar lavage. Restriction fragment length polymorphism analysis on both isolates of M. tuberculosis revealed a common source. The donor of both lungs had a normal chest radiograph and no known prior history of M. tuberculosis infection of disease. These cases are the first report of two single lung recipients developing pulmonary tuberculosis from a common donor.
由于免疫抑制以及微生物通过供体器官传播，器官移植受者感染风险增加。我们报告了两例接受单肺移植的受者感染结核分枝杆菌的病例，他们共用一位供体。两名受者均患上肺结核，一名出现发热和肺部浸润，另一名为亚临床疾病，支气管肺泡灌洗中检出结核分枝杆菌。对两份结核分枝杆菌分离株进行的限制性片段长度多态性分析显示来源相同。两位供肺者胸部X光片正常，既往无已知结核分枝杆菌感染或疾病史。这些病例是首例关于两名单肺移植受者因共用供体而患上肺结核的报告。
