Zala L, Omar A, Krebs A
Dermatologica. 1977;154(4):203-15. doi: 10.1159/000251067.
Two patients, who we had under surveillance since 1969, were found to develop photo-onycholysis from orally administered 8-methoxypsoralen and sunlight irradiation. Morphological examination of the nail bed revealed characteristics of a microtrauma. The photosensitizing effect of the drug induced the generation numerous binucleate, tetranucleate and multinucleate epithelial cells as well as numerous binucleate and tetranucleate fibroblasts in the dermis.
自1969年起，我们就对两名患者进行了监测，发现他们在口服8-甲氧基补骨脂素并接受阳光照射后出现了光甲剥离症。对甲床的形态学检查显示出微创伤的特征。该药物的光敏作用导致真皮中产生大量双核、四核和多核上皮细胞以及大量双核和四核成纤维细胞。
