O'Mahony D, Coffey J, Murphy J, O'Hare N, Hamilton D, Rowan M, Freyne P, Walsh J B, Coakley D
Mercer's Institute for Research on Ageing, St. James's hospital, Dublin.
J Gerontol A Biol Sci Med Sci. 1996 May;51(3):M102-7. doi: 10.1093/gerona/51a.3.m102.
The N2 and P3 components of auditory event-related potentials (ERPs) and single-photon emission computed tomographic (SPECT) images are separate independent biological markers of cerebral function and are abnormal in Alzheimer's disease (AD). The relationship between ERP N2 and P3 latencies and regional cerebral perfusion abnormalities in AD is unknown.
ERP and SPECT data were obtained one week apart in 18 patients with "probable" AD of mild or moderate severity, and 12 healthy age-matched elderly controls. Average premotor frontal, anterior temporal, inferior parietal, and occipital cortical/cerebellar perfusion ratios were calculated from the SPECT data and correlations with ERP N2 and P3 latencies derived for AD and control groups separately.
ERP N2 latency was correlated significantly with the average frontal perfusion ratio (r = -.59; p < .009), but correlations with average temporal, parietal, and occipital ratios were nonsignificant in the AD group. Similarly, ERP P3 latency was correlated significantly with the average frontal perfusion ratio (r = -.65; p < .004), but not with the other perfusion ratios in the AD group. In the control group, a partial correlation between the average frontal perfusion ratio and the ERP N2 latency was noted (r = -.52; p < .09), but no other ERP/SPECT correlations approached statistical significance.
ERP N2 and P3 latency delay in AD is a function of differential frontal lobe hypoperfusion.
听觉事件相关电位（ERP）的N2和P3成分以及单光子发射计算机断层扫描（SPECT）图像是脑功能的独立生物学标志物，在阿尔茨海默病（AD）中异常。AD中ERP的N2和P3潜伏期与局部脑灌注异常之间的关系尚不清楚。
对18例轻度或中度“可能”AD患者和12名年龄匹配的健康老年对照者，相隔一周获取ERP和SPECT数据。从SPECT数据计算运动前区额叶、颞叶前部、顶叶下部和枕叶皮质/小脑的平均灌注率，并分别得出AD组和对照组与ERP N2和P3潜伏期的相关性。
AD组中，ERP N2潜伏期与额叶平均灌注率显著相关（r = -0.59；p < 0.009），但与颞叶、顶叶和枕叶平均灌注率的相关性不显著。同样，ERP P3潜伏期与额叶平均灌注率显著相关（r = -0.65；p < 0.004），但与AD组的其他灌注率无关。在对照组中，注意到额叶平均灌注率与ERP N2潜伏期之间存在部分相关性（r = -0.52；p < 0.09），但没有其他ERP/SPECT相关性接近统计学显著性。
AD中ERP N2和P3潜伏期延迟是额叶不同程度灌注不足的结果。
