阿尔茨海默病患者 P300 潜伏期和振幅：系统评价。
P300 latency and amplitude in Alzheimer's disease: a systematic review.
机构信息
Universidade Estadual Paulista Júlio de Mesquita Filho.
出版信息
Braz J Otorhinolaryngol. 2012 Jul-Aug;78(4):126-32. doi: 10.1590/S1808-86942012000400023.
UNLABELLED
The P300 plays a key role as a method for monitoring and evaluating dementia, including Alzheimer's disease.
OBJECTIVE
The goal of this study was to search for articles which analyzed P300 latency and amplitude values in Alzheimer's disease.
METHODS
We searched in the following databases: Web of Science, Pub Med, Psyc Info, Medline, Biological Abstracts and Scielo using the following keywords: speed of information processing, processing speed, information processing, aged, older, elderly, older people, alzheimer dementia, alzheimer disease, Alzheimer and cross-references of selected articles.
RESULTS
We found eight studies matching the inclusion criteria. These studies showed that there is a consensus on a P300 latency increase of elderly patients with Alzheimer's disease compared with subjects without the disease. However, it appears that, with respect to the P300 amplitude, there is still no consensus; however, it may be related to different methodological variables adopted in the reviewed studies.
CONCLUSION
There is a need to standardize the variables involved in P300 measurement for senior citizens with Alzheimer's disease in order to be able to compare P300 latency and amplitude values for this population.
未加标签
P300 作为一种监测和评估痴呆症（包括阿尔茨海默病）的方法发挥着关键作用。
目的
本研究旨在寻找分析阿尔茨海默病患者 P300 潜伏期和振幅值的文章。
方法
我们在以下数据库中进行了搜索：Web of Science、Pub Med、Psyc Info、Medline、Biological Abstracts 和 Scielo，使用了以下关键词：信息处理速度、处理速度、信息处理、年龄、老年、老年人、老年人、阿尔茨海默病痴呆、阿尔茨海默病、阿尔茨海默和选定文章的参考文献。
结果
我们发现了 8 项符合纳入标准的研究。这些研究表明，与没有患病的受试者相比，阿尔茨海默病老年患者的 P300 潜伏期增加存在共识。然而，关于 P300 振幅似乎仍然没有共识；然而，这可能与综述研究中采用的不同方法学变量有关。
结论
有必要为患有阿尔茨海默病的老年人标准化 P300 测量中涉及的变量，以便能够比较该人群的 P300 潜伏期和振幅值。
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