Pejovic T, Alm P, Iosif S C, Mitelman F, Heim S
Department of Gynecologic Oncology, University Hospital, Lund, Sweden.
Cancer Genet Cytogenet. 1996 May;88(1):53-6. doi: 10.1016/0165-4608(95)00291-x.
Short-term cultures of four malignant mixed mesodermal tumors of the ovary were cytogenetically analyzed. The primary tumor was examined in three cases, whereas in one case the sample was obtained from a residual tumor mass after chemotherapy. The tumor sampled after cytostatic treatment had a relatively simple karyotype with numerical changes that included pentasomy 12 and an i(1)(q10) as the only structural abnormality. Karyotypic analysis of the three primary tumors revealed extensive structural as well as numerical aberrations, i.e., a picture similar to that seen in the few malignant mixed mesodermal tumors with karyotypic anomalies described previously. Rearrangements of chromosome 1, leading to loss of distal 1p, and homogeneously staining regions have so far been the most frequent cytogenetic changes in this tumor type. Malignant mixed mesodermal tumors of the ovary thus seem to be karyotypically identical to the more numerous mixed mesodermal tumors of uterine origin, and they do not differ substantially in this respect from pure ovarian carcinomas.
对4例卵巢恶性混合性中胚层肿瘤进行了短期培养，并进行了细胞遗传学分析。3例检查了原发肿瘤，1例样本取自化疗后的残留肿瘤块。经细胞抑制治疗后取样的肿瘤具有相对简单的核型，有数目改变，包括12号染色体五体性和作为唯一结构异常的i(1)(q10)。对3例原发肿瘤的核型分析显示有广泛的结构和数目畸变，即与先前描述的少数有核型异常的恶性混合性中胚层肿瘤所见的情况相似。1号染色体重排导致1p远端缺失，以及均匀染色区，是迄今为止该肿瘤类型最常见的细胞遗传学改变。因此，卵巢恶性混合性中胚层肿瘤在核型上似乎与更多的子宫源性混合性中胚层肿瘤相同，并且在这方面与纯卵巢癌没有实质性差异。
