Pejovic T, Iosif C S, Mitelman F, Heim S
Department of Gynecologic Oncology, University Hospital, Lund, Sweden.
Cancer Genet Cytogenet. 1996 Dec;92(2):95-8. doi: 10.1016/s0165-4608(96)00169-0.
Clonal karyotypic abnormalities were detected in five of 14 cytogenetically analyzed borderline malignant ovarian tumors of clinical stages I-II. One mucinous and one seropapillary tumor had trisomy 7 and r(1)(p36q42) as the sole chromosome abnormality, respectively. Trisomy 12 was found in the remaining three cases. It was the only change in one mucinous and one serous tumor, whereas the third, a seropapillary borderline tumor, had the karyotype 49,XX,+5,+8, +12. These findings, especially when collated with those of previous reports on ovarian borderline tumor cytogenetics, indicate that +12 is the most consistent chromosomal aberration in this group of neoplasms and that also +7 and r(1) are nonrandom features. From the karyotypic point of view, benign ovarian tumors and well-differentiated carcinomas are similar to borderline ovarian tumors, with the possible exception that the former have no tendency to form r(1). Highly malignant carcinomas, on the other hand, are typically much more complex. Chromosome-level changes therefore cannot account for the putative phenotypic passage through the most innocuous tumor stages as epithelial ovarian neoplasms go from benign to fully malignant.
在14例经细胞遗传学分析的临床I-II期交界性恶性卵巢肿瘤中，有5例检测到克隆性核型异常。1例黏液性肿瘤和1例浆液性乳头状肿瘤分别以7号染色体三体和r(1)(p36q42)作为唯一的染色体异常。其余3例发现12号染色体三体。在1例黏液性肿瘤和1例浆液性肿瘤中，12号染色体三体是唯一的变化，而第3例，即1例浆液性乳头状交界性肿瘤，其核型为49,XX,+5,+8,+12。这些发现，尤其是与先前关于卵巢交界性肿瘤细胞遗传学的报告结果进行对比时，表明12号染色体三体是这组肿瘤中最一致的染色体畸变，而且7号染色体三体和r(1)也是非随机特征。从核型的角度来看，良性卵巢肿瘤和高分化癌与交界性卵巢肿瘤相似，可能的例外是前者没有形成r(1)的倾向。另一方面，高恶性癌通常要复杂得多。因此，染色体水平的变化无法解释上皮性卵巢肿瘤从良性发展到完全恶性过程中最无害肿瘤阶段的假定表型转变。
