结直肠肿瘤中的血清胸苷激酶

Serum thymidine kinase in colorectal neoplasia.

作者信息

Thomas W M, Robertson J F, McKenna P G, O'Neill K L, Robinson M H, Hardcastle J D

机构信息

University Hospital, Nottingham, UK.

出版信息

Eur J Surg Oncol. 1995 Dec;21(6):632-4. doi: 10.1016/s0748-7983(95)95434-1.

DOI:10.1016/s0748-7983(95)95434-1

PMID:8631410

Abstract

Thymidine kinase (TK), an enzyme known to be associated with DNA synthesis, has been measured in the serum of patients with asymptomatic colorectal adenomas (n = 40), asymptomatic colorectal carcinoma (n = 21) and patients known to have hepatic metastases form colorectal tumours (n = 33); enzyme levels have been compared with an age-matched group of asymptomatic people with no evidence of colorectal neoplasia at screening colonoscopy (n = 26). TK activity in patients with metastatic disease (median 4.23; range 2.03-14.12 pmol/ml/h) and in patients with adenomas (median 2.33; range 1.59-8.73 pmol/ml/h) was significantly higher than in the normal controls (median 2.04; range 1.29-5.40 pmol/ml/h). However TK activity in patients with asymptomatic cancer (median 1.85; range 1.00-4.50 pmol/ml/h) was not significantly different from the control group.

摘要

胸苷激酶（TK）是一种已知与DNA合成相关的酶，已在无症状结肠直肠腺瘤患者（n = 40）、无症状结肠直肠癌患者（n = 21）以及已知有结直肠肿瘤肝转移的患者（n = 33）的血清中进行了检测；酶水平已与一组年龄匹配的、在筛查结肠镜检查时无结直肠肿瘤证据的无症状人群（n = 26）进行了比较。转移性疾病患者（中位数4.23；范围2.03 - 14.12 pmol/ml/h）和腺瘤患者（中位数2.33；范围1.59 - 8.73 pmol/ml/h）的TK活性显著高于正常对照组（中位数2.04；范围1.29 - 5.40 pmol/ml/h）。然而，无症状癌症患者（中位数1.85；范围1.00 - 4.50 pmol/ml/h）的TK活性与对照组无显著差异。