D'Ambra-Cabry K, Tharp M D, Jagasothy B V, Deng J S
University of Pittsburgh Department of Dermatology, PA, USA.
J Am Acad Dermatol. 1996 May;34(5 Pt 1):777-80. doi: 10.1016/s0190-9622(96)90012-2.
Recent evidence suggests that as cutaneous T-cell lymphoma progresses, cell-mediated immunity is reduced and humoral responses are augmented.
The present study was designed to compare the IgG response in Sézary syndrome with that in mycosis fungoides.
The IgG antilymphocyte response was studied in six patients with Sézary syndrome and in 11 patients with mycosis fungoides by means of immunoblot analysis, enzyme-linked immunosorbent assay, immunohistochemistry, and flow cytometry.
An IgG antilymphocyte response to a 50 kd peptide was seen in five of the six patients with Sézary syndrome; however, none of the 11 patients with mycosis fungoides expressed this response.
An enhanced IgG immune response to 50 kd lymphocyte peptide may be helpful in identifying disease progression in patients with cutaneous T-cell lymphoma.
最近的证据表明，随着皮肤T细胞淋巴瘤的进展，细胞介导的免疫反应降低，而体液反应增强。
本研究旨在比较 Sézary 综合征与蕈样肉芽肿患者的 IgG 反应。
通过免疫印迹分析、酶联免疫吸附测定、免疫组织化学和流式细胞术，对6例 Sézary 综合征患者和11例蕈样肉芽肿患者的IgG抗淋巴细胞反应进行了研究。
6例 Sézary 综合征患者中有5例对50kd 肽出现 IgG 抗淋巴细胞反应；然而，11例蕈样肉芽肿患者均未表现出这种反应。
对50kd淋巴细胞肽的IgG免疫反应增强可能有助于识别皮肤T细胞淋巴瘤患者的疾病进展。
