Forkmann G, Seyffert W
Genetics. 1977 Mar;85(3):557-72. doi: 10.1093/genetics/85.3.557.
Investigations on metric characters of defined genotypes of Matthiola incana, and application of different linear models for the estimation of genetic parameters, indicate that the use of midparental value as a reference point results in parameter estimates that do not correspond to the actual biological situation. Use of the most recessive genotype as a reference point causes all of the contributions of single loci to be undirectional and positive, and all the allelic and nonallelic interactions to be unidirectional and negative, in accord with our Model 2.2. The results indicate that the phenotypic response to allelic substitutions follows the characteristics of a saturation curve. The possibility is discussed that the saturation character results from regulating processes, whereas deviations of single measurements from the response curve, or response surface, reflect real interactions between allelic and nonallelic genes.
对紫罗兰特定基因型的度量性状进行研究，并应用不同线性模型估计遗传参数，结果表明，以中亲值作为参考点会导致参数估计值与实际生物学情况不符。以最隐性基因型作为参考点，会使单个位点的所有贡献都是单向且正向的，所有等位基因和非等位基因相互作用都是单向且负向的，这与我们的模型2.2一致。结果表明，对等位基因替代的表型反应遵循饱和曲线的特征。文中讨论了饱和特征可能源于调控过程，而单次测量值与反应曲线或反应面的偏差反映了等位基因和非等位基因之间的真实相互作用。
