Funaki N, Arii S, Monden K, Tanaka J, Imamura M
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Life Sci. 1996;58(7):551-9. doi: 10.1016/0024-3205(95)02324-0.
We analyzed primary-cultured human hepatic macrophages (HHMphi) from 12 patients with non-cirrhotic and cirrhotic livers for cell surface expression of HLA-DR antigen and interleukin-2 receptor (IL-2R). Compared to the relatively abundant HLA-DR antigen, IL-2R expression was generally low. No significant difference was observed between HLA-DR antigen expression nor IL-2 receptor expression. HHMphi from patients with serum hepatitis viral markers, however, expressed significantly more HLA-DR antigen than did HHMphi of patients without viral markers, which suggest a possible role of HHMphi as antigen-presenting cells (APC) in viral hepatitis. This direct, quantitative measurement of cell surface molecule expression on hepatic macrophages of human may provide an important clue to the pathophysiology of human liver disorders.
我们分析了来自12例非肝硬化和肝硬化患者的原代培养人肝巨噬细胞（HHMphi）的HLA - DR抗原和白细胞介素 - 2受体（IL - 2R）的细胞表面表达。与相对丰富的HLA - DR抗原相比，IL - 2R表达通常较低。HLA - DR抗原表达和IL - 2受体表达之间未观察到显著差异。然而，有血清肝炎病毒标志物患者的HHMphi比没有病毒标志物患者的HHMphi表达显著更多的HLA - DR抗原，这表明HHMphi作为抗原呈递细胞（APC）在病毒性肝炎中可能发挥作用。这种对人肝巨噬细胞表面分子表达的直接定量测量可能为人类肝脏疾病的病理生理学提供重要线索。
