Goodgold H M, Fletcher J W, Steinhardt G F
Division of Nuclear Medicine and Urology, St. Louis University Health Sciences Center, Missouri 63110, USA.
Urology. 1996 Mar;47(3):405-8. doi: 10.1016/s0090-4295(99)80461-0.
To develop a method for assessing absolute renal function (as well as morphology) in children, using gamma camera imaging of intravenously injected technetium-99m (99mTc) dimercaptosuccinic acid (DMSA).
Forty-five children (ages 1 week to 10 years; mean, 2.0 years) were imaged using a planar technique in which not only the appearance but the absolute amount of intravenously administered 99mTc DMSA taken up by the kidneys was calculated for each child and compared with contemporaneous determinations of creatinine clearance.
There was a close correlation between the absolute DMSA uptake and creatinine clearance (r = 0.752).
Renal function in children, expressed as creatinine clearance, can be accurately estimated by measuring absolute DMSA uptake with planar gamma camera imaging using 99mTc DMSA.
利用静脉注射锝-99m（99mTc）二巯基丁二酸（DMSA）后γ相机成像技术，开发一种评估儿童绝对肾功能（以及形态）的方法。
对45名儿童（年龄1周至10岁；平均2.0岁）采用平面技术进行成像，该技术不仅计算每个儿童肾脏摄取的静脉注射99mTc DMSA的外观，还计算其绝对量，并与同时测定的肌酐清除率进行比较。
DMSA绝对摄取量与肌酐清除率之间存在密切相关性（r = 0.752）。
通过使用99mTc DMSA的平面γ相机成像测量DMSA绝对摄取量，可以准确估计以肌酐清除率表示的儿童肾功能。
