Kao J H, Lai M Y, Chen P J, Hwang L H, Chen W, Chen D S
Department of Internal Medicine, Graduate Institute of Clinical Medicine and Hepatitis Research Center, National Taiwan University Hospital.
Am J Gastroenterol. 1996 Mar;91(3):506-10.
To investigate the relationship between serum hepatitis C virus (HCV) titers and clinicopathological characteristics of chronic type C hepatitis.
Serum HCV cDNA concentrations were determined by a competitive polymerase chain reaction assay in 60 Taiwanese patients with chronic type C hepatitis.
The concentration of serum HCV cDNA ranged between 10(2) and 10(8) copies/mL. The titers of serum HCV (logarithmic transformed copies of HCV cDNA/mL serum) were not significantly correlated with clinicopathological characteristics with respect to either sex of the patients, source of infection, higher serum ALT level (>150 IU/L) or histological severity. In contrast, serum HCV titers were significantly higher in patients with age above 50 yr and with type 1b HCV infection. Moreover, the influence of advancing age on serum HCV titer was genotype-independent by multivariate analysis.
These results suggest that advancing age and genotype are both important determinants of HCV viremia and that the pathogenesis of HCV infection might not be caused by direct cytotoxicity of the virus.
探讨血清丙型肝炎病毒（HCV）滴度与慢性丙型肝炎临床病理特征之间的关系。
采用竞争性聚合酶链反应法测定60例台湾慢性丙型肝炎患者血清HCV cDNA浓度。
血清HCV cDNA浓度在10²至10⁸拷贝/毫升之间。血清HCV滴度（HCV cDNA/毫升血清的对数转换拷贝数）与患者性别、感染源、较高血清ALT水平（>150 IU/L）或组织学严重程度等临床病理特征均无显著相关性。相比之下，年龄在50岁以上且感染1b型HCV的患者血清HCV滴度显著更高。此外，多因素分析表明年龄增长对血清HCV滴度的影响与基因型无关。
这些结果表明，年龄增长和基因型都是HCV病毒血症的重要决定因素，且HCV感染的发病机制可能不是由病毒的直接细胞毒性引起的。
