Davidge S T, Stranko C P, Roberts J M
Magee-Womens Research Institute, Pittsburgh, PA 15213, USA.
Am J Obstet Gynecol. 1996 Mar;174(3):1008-13. doi: 10.1016/s0002-9378(96)70341-1.
Nitric oxide is a potent vasorelaxant produced by endothelial cells. We tested the hypothesis that urinary and perhaps plasma nitric oxide metabolites would be reduced in women with preeclampsia.
Plasma and urine from 14 women meeting strict clinical criteria for the diagnosis of preeclampsia and 20 normal nulliparous women were assayed for the stable metabolites of nitric oxide, nitrate and nitrite.
There was no significant difference of plasma concentrations of nitrate and nitrite between women with preeclampsia and women with normal pregnancies (32.7 +/- 3.1 vs 25.8 +/- 2.4 micromol/L). Plasma creatinine levels were elevated in women with preeclampsia (0.85 +/- 0.09 vs 0.66 +/- 0.02 mg/dl, p<0.01), indicating a reduced glomerular filtration rate. Urine concentrations of nitrate and nitrite normalized by creatinine excretion were significantly lower in women with preeclampsia compared with normal pregnant women (0.37 +/- 0.06 vs 0.69 +/- 0.11 micromol of nitrite per milligram creatinine, p. <0.05).
Our study using concomitant measurement of plasma and urine nitrate and nitrite suggests a reduced production of nitric oxide in women with preeclampsia compared with normal pregnant women.
一氧化氮是一种由内皮细胞产生的强效血管舒张剂。我们检验了这样一个假设，即子痫前期女性的尿液以及可能的血浆中的一氧化氮代谢产物会减少。
对14名符合子痫前期诊断严格临床标准的女性和20名正常未生育女性的血浆和尿液进行一氧化氮的稳定代谢产物硝酸盐和亚硝酸盐的检测。
子痫前期女性与正常妊娠女性的血浆硝酸盐和亚硝酸盐浓度无显著差异（分别为32.7±3.1和25.8±2.4微摩尔/升）。子痫前期女性的血浆肌酐水平升高（分别为0.85±0.09和0.66±0.02毫克/分升，p<0.01），表明肾小球滤过率降低。子痫前期女性经肌酐排泄校正后的尿液硝酸盐和亚硝酸盐浓度显著低于正常妊娠女性（分别为每毫克肌酐0.37±0.06和0.69±0.11微摩尔亚硝酸盐，p<0.05）。
我们同时测量血浆和尿液硝酸盐及亚硝酸盐的研究表明，与正常妊娠女性相比，子痫前期女性的一氧化氮生成减少。
