Chari R S, Friedman S A, Schiff E, Frangieh A T, Sibai B M
Department of Obstetrics and Gynecology, University of Tennessee, Memphis, USA.
Am J Obstet Gynecol. 1996 Mar;174(3):829-32. doi: 10.1016/s0002-9378(96)70308-3.
Our objective was to determine whether the Ballard score, a maturity score for neonatal neuromuscular and physical development, is more advanced in preterm infants of preeclamptic women than in controls.
A matched cohort study design was used. One hundred women with strictly defined preeclampsia (new-onset hypertension, proteinuria, and hyperuricemia) were matched for gestational age, race, and gender to 100 normotensive women with preterm delivery. All patients had an assigned antenatal gestational age based on ultrasonography before 24 weeks. The gestational age, based on antenatal ultrasonography and last menstrual period, was compared with the Ballard score given at the time of neonatal physical examination within the first 12 hours after delivery. The difference in gestational age between the Ballard score and antenatal ultrasonography (Ballard score - ultrasonography) was calculated for each patient. Results are expressed as median and range and are compared with a Student t test.
The mean gestational age at delivery by antenatal ultrasonography in patients with severe preeclampsia was 32.06 +/- 2.74 and 32.03 +/- 2.70 weeks, respectively. The median difference between scores in patients with severe preeclampsia and normal patient were 1.3 +/- 1.8 and 1.5 +/- 1.6 weeks, respectively (p = 0.41).
On the basis of criteria defined by the Ballard score, preeclampsia was not associated with accelerated fetal neurologic and physical development.
我们的目的是确定巴拉德评分（一种用于评估新生儿神经肌肉和身体发育的成熟度评分）在子痫前期孕妇的早产儿中是否比对照组更超前。
采用匹配队列研究设计。100例严格定义为子痫前期（新发高血压、蛋白尿和高尿酸血症）的孕妇与100例早产的血压正常孕妇按孕周、种族和性别进行匹配。所有患者在孕24周前均根据超声检查确定了产前孕周。将基于产前超声检查和末次月经计算的孕周与出生后12小时内新生儿体格检查时给出的巴拉德评分进行比较。计算每位患者巴拉德评分与产前超声检查之间的孕周差异（巴拉德评分-超声检查）。结果以中位数和范围表示，并采用Student t检验进行比较。
重度子痫前期患者产前超声检查的平均分娩孕周分别为32.06±2.74周和32.03±2.70周。重度子痫前期患者与正常患者评分的中位数差异分别为1.3±1.8周和1.5±1.6周（p = 0.41）。
根据巴拉德评分定义的标准，子痫前期与胎儿神经和身体发育加速无关。
