Sintes J L, Escalante C, Stewart B, McCool J J, Garcia L, Volpe A R, Triol C
Colgate-Palmolive Technology Center, Piscataway, NJ 08854, USA.
Am J Dent. 1995 Oct;8(5):231-5.
To evaluate the efficacy of a sodium fluoride (NaF)/silica/xylitol dentifrice compared with that of a positive control NaF/silica dentifrice on caries increments in school children over a 3-year period in an area without an optimal level of fluoride in the drinking water (mean level <0.1 ppm).
A 3-year, double-blind clinical caries study was conducted in 2,630 children initially aged 8-10 years at 17 schools in the San Jose, Costa Rica metropolitan area. Clinical dental examinations were performed at participating schools utilizing portable dental equipment. Caries evaluations employed conventional tactile/visual methodology consisting of artificial light, dental mirrors and single-edge #23 explorers. Children accepted into the study were stratified by age and sex into two balanced groups within each school, and randomly assigned to use either a positive control dentifrice containing 0.243% NaF/silica or a test dentifrice containing 0.234% NaF/silica/10% xylitol. Children were instructed to brush with the assigned dentifrice twice daily. Caries evaluations were conducted at baseline, 2 years, and 3 years.
After 3 years, subjects using the 0.234% NaF/silica/10% xylitol dentifrice had statistically significantly reduced decayed/filled surfaces (DFS; -12.3% reduction; P < or = 0.001) and decayed/filled buccal and lingual surfaces (DFS-BL; -10.5% reduction; P < or = 0/01).
在饮用水中氟含量未达最佳水平（平均水平<0.1 ppm）的地区，评估含氟化钠（NaF）/二氧化硅/木糖醇牙膏与阳性对照含NaF/二氧化硅牙膏相比，对学龄儿童3年内龋齿增量的影响。
在哥斯达黎加圣何塞大都会区的17所学校，对2630名初始年龄为8 - 10岁的儿童进行了一项为期3年的双盲临床龋齿研究。利用便携式牙科设备在参与研究的学校进行临床牙科检查。龋齿评估采用传统的触觉/视觉方法，包括人工照明、牙科镜和单刃#23探针。纳入研究的儿童按年龄和性别在每所学校内分为两个均衡组，并随机分配使用含0.243% NaF/二氧化硅的阳性对照牙膏或含0.234% NaF/二氧化硅/10%木糖醇的试验牙膏。指导儿童每天使用指定牙膏刷牙两次。在基线、2年和3年时进行龋齿评估。
3年后，使用含0.234% NaF/二氧化硅/10%木糖醇牙膏的受试者，其龋坏/充填面（DFS；减少12.3%；P≤0.001）以及龋坏/充填的颊面和舌面（DFS - BL；减少10.5%；P≤0.01）在统计学上有显著降低。
