Kowalczyk-Bronisz S H, Giełdanowski J
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):931-3.
The influence of conjugate 6MP with bovine gamma-globulin on some cellular immunologic reactions was investigated. The animals were immunized with the protein carrier and then conjugate or its components, in not coupled form, were introduced. Selective, but not strong, suppression of the immunological answer was observed in the migration inhibition of the mice splenocytes and the foot pad test. Conjugate was not changing the activity of the factor increasing vascular permeability. It was also confirmed, that conjugates of the nonsteroidal antiinflammatory drugs, except for conjugate of phenylbutazone with HSA, were not different in its influence (in the hyperaemic and oedema tests) from the individual components in not coupled form.
研究了6-巯基嘌呤与牛γ球蛋白的偶联物对某些细胞免疫反应的影响。用蛋白质载体免疫动物，然后引入偶联物或其未偶联形式的组分。在小鼠脾细胞迁移抑制试验和足垫试验中观察到免疫应答受到选择性但不强烈的抑制。偶联物未改变增加血管通透性因子的活性。还证实，除了保泰松与HSA的偶联物外，非甾体抗炎药的偶联物在充血和水肿试验中的影响与未偶联形式的单个组分没有差异。
