Paquet P, Piérard G E
Department of Dermatopathology, University of Liège, Belgium.
Int Arch Allergy Immunol. 1996 Apr;109(4):308-17. doi: 10.1159/000237257.
Interleukin-6 is a pleiotropic cytokine with numerous biological activities. It is produced by normal constituents of the skin, including epidermal cells, fibroblasts and dermal endothelial cells. It is also synthesized by inflammatory cells infiltrating the skin in various pathological conditions. We reviewed the presumed activities of interleukin-6 in normal skin and in some diseases with cutaneous involvement. The action of some drugs used in dermatology was also considered with regard to the modulation of the cytokine release. It is concluded that several important cellular lineages of the skin release interleukin-6. The cytokine appears to play a crucial role in the pathogenesis of both local and systemic inflammation, tumor development and autoimmune diseases.
白细胞介素-6是一种具有多种生物学活性的多效性细胞因子。它由皮肤的正常成分产生，包括表皮细胞、成纤维细胞和真皮内皮细胞。在各种病理状况下浸润皮肤的炎症细胞也能合成白细胞介素-6。我们综述了白细胞介素-6在正常皮肤以及一些有皮肤受累的疾病中的假定活性。还考虑了一些皮肤科用药在调节细胞因子释放方面的作用。得出的结论是，皮肤的几个重要细胞谱系会释放白细胞介素-6。该细胞因子似乎在局部和全身炎症、肿瘤发展及自身免疫性疾病的发病机制中起关键作用。
