Piacquadio D, Dobry M, Hunt S, Andree C, Grove G, Hollenbach K A
Division of Dermatology, University of California, San Diego, USA.
Dermatol Surg. 1996 May;22(5):449-52. doi: 10.1111/j.1524-4725.1996.tb00346.x.
Glycolic acid has been one of the more commonly used alpha hydroxy acids for the treatment of photodamaged skin. Its value as a quick "skin refreshing" peeling agent has been widely touted. This type of peel differs from a conventional therapeutic peel (eg, phenol, trichloroacetic acid, or a longer time exposure alpha hydroxy acid peel) in that there is little skin reaction and patients can go about their daily routine without concern.
To assess the potential value of glycolic acid-based refresher peels as a cosmetic procedure.
Twelve healthy subjects with at least a moderate degree of photodamage were treated with monthly serial 70% glycolic acid peels over a period of 4 months. In addition to the "peels," six subjects were randomized to a 10% glycolic acid-based moisturizer twice daily. Patients were evaluated monthly and graded on a clinical scale using objective measures.
No conclusive differences were noted on histologic evaluation. Ninety percent (9/10) of patients felt that overall they noticed significant improvement, however, there was no distinction between the two treatment options. The improvement in fine wrinkling and pigmentation was primarily seen in the patients who additionally received 10% glycolic emollient twice daily.
In this limited pilot study, no specific benefit could be assigned to the concomitant use of monthly glycolic acid refresher "peels" in the treatment of photodamaged skin.
乙醇酸一直是治疗光损伤皮肤时较为常用的α-羟基酸之一。其作为一种快速“焕肤”剥脱剂的价值已得到广泛宣传。这种剥脱术与传统治疗性剥脱术（如苯酚、三氯乙酸或长时间暴露的α-羟基酸剥脱术）不同，其皮肤反应较小，患者可以照常进行日常活动而无需担忧。
评估基于乙醇酸的焕肤术作为一种美容程序的潜在价值。
12名至少有中度光损伤的健康受试者在4个月内每月接受一系列70%乙醇酸剥脱术治疗。除了“剥脱术”外，6名受试者被随机分配至每天两次使用含10%乙醇酸的保湿霜。每月对患者进行评估，并使用客观指标按临床量表进行评分。
组织学评估未发现确凿差异。然而，90%（9/10）的患者认为总体上有显著改善，但两种治疗方案之间并无差异。细纹和色素沉着的改善主要见于额外每天两次使用10%乙醇酸润肤剂的患者。
在这项有限的初步研究中，对于在光损伤皮肤治疗中每月同时使用乙醇酸焕肤“剥脱术”，无法确定其有特定益处。
