Gold Michael H, Hu Judy Y, Biron Julie A, Yatskayer Margarita, Dahl Amanda, Oresajo Christian
J Clin Aesthet Dermatol. 2011 Oct;4(10):40-8.
All-trans retinoic acid is a well-established topical treatment of photodamaged skin. This study assessed the tolerance and efficacy of all-trans retinoic acid after full-face treatment with a chemical peel.
This was a split-face, randomized study. One side of each face was treated with peel and the other side with peel and all-trans retinoic acid (3%). Four treatments were given during the 10-week study period.
Physician office.
Fifteen female subjects 39 to 55 years of age.
RESULTS were evaluated at Baseline; Weeks 4, 7, and 10; and at a 13-week follow-up visit by dermal grading of visual symptoms of irritation, subjective experiences of irritation, clinical grading of skin condition, and self-assessment questionnaires.
Both peel and peel plus all-trans retinoic acid treatments achieved significant improvement in fine lines, radiance, roughness, skin tone clarity, skin tone evenness, and hyperpigmentation appearance. Improvement in wrinkles and firmness was not observed in the peel plus all-trans retinoic acid arm, while pore appearance failed to improve in either treatment arm. Improvement in overall facial appearance was greater in the peel alone arm. Peel alone and the addition of all-trans retinoic acid did not cause dryness, edema, or peeling, and the frequency of peel-induced erythema did not increase with the addition of all-trans retinoic acid. Subject-perceived improvements with the peel treatment did not differ significantly from subject-perceived improvements of the peel plus all-trans retinoic acid treatment. Adverse events requiring intervention or discontinuing treatment were not observed in either treatment arm.
The addition of all-trans retinoic acid after peel treatment does not significantly enhance peel-induced improvement in photoaging parameters, peel-induced adverse effects, and subject-perceived improvements.
全反式维甲酸是一种公认的光损伤皮肤局部治疗药物。本研究评估了化学换肤全脸治疗后使用全反式维甲酸的耐受性和疗效。
这是一项半脸随机研究。每侧面部一侧进行换肤治疗，另一侧进行换肤加全反式维甲酸（3%）治疗。在为期10周的研究期间进行了4次治疗。
医生办公室。
15名39至55岁的女性受试者。
在基线、第4周、第7周和第10周以及13周随访时，通过对刺激视觉症状的皮肤分级、刺激主观体验、皮肤状况临床分级和自我评估问卷来评估结果。
换肤治疗和换肤加全反式维甲酸治疗在细纹、光泽度、粗糙度、肤色清晰度、肤色均匀度和色素沉着外观方面均取得了显著改善。换肤加全反式维甲酸组未观察到皱纹和紧致度的改善，而两个治疗组的毛孔外观均未改善。仅换肤组的整体面部外观改善更大。单独换肤和添加全反式维甲酸均未引起干燥、水肿或脱皮，且添加全反式维甲酸后换肤引起的红斑频率未增加。受试者对换肤治疗的感知改善与换肤加全反式维甲酸治疗的感知改善无显著差异。两个治疗组均未观察到需要干预或停止治疗的不良事件。
换肤治疗后添加全反式维甲酸并不能显著增强换肤诱导的光老化参数改善、换肤诱导的不良反应和受试者感知的改善。
