Singletary K, MacDonald C, Wallig M, Fisher C
Department of Food Science and Human Nutrition, University of Illinois, Urbana 61801, USA.
Cancer Lett. 1996 Jun 5;103(2):137-41. doi: 10.1016/0304-3835(96)04224-3.
Curcumin, a constituent of the traditional Indian spice and medicine turmeric, was evaluated for its capacity to inhibit the mammary tumor initiating activity of 7,12-dimethylbenz[a]anthracene (DMBA) and the in vivo formation of mammary DMBA-DNA adducts in the female rat. Administration (i.p.) of curcumin at 100 mg/kg and 200 mg/kg doses was associated with a significant decrease in the number of palpable mammary tumors and mammary adenocarcinomas. The in vivo formation of mammary DMBA-DNA adducts also was depressed for animals administered curcumin doses from 50 mg/kg to 200 mg/kg. There was, however, no significant enhancement of liver glutathione-S-transferase activity following curcumin administration. Therefore, curcumin when administered i.p. can act as an effective chemopreventative agent towards DMBA-induced rat mammary tumorigenesis and mammary adduct formation.
姜黄素是传统印度香料和药物姜黄的一种成分，我们评估了它抑制7,12-二甲基苯并[a]蒽（DMBA）引发雌性大鼠乳腺肿瘤的能力以及乳腺中DMBA-DNA加合物的体内形成情况。腹腔注射100毫克/千克和200毫克/千克剂量的姜黄素与可触及乳腺肿瘤和乳腺腺癌数量的显著减少相关。对于腹腔注射50毫克/千克至200毫克/千克剂量姜黄素的动物，乳腺中DMBA-DNA加合物的体内形成也受到抑制。然而，注射姜黄素后肝脏谷胱甘肽-S-转移酶活性没有显著增强。因此，腹腔注射姜黄素可作为一种有效的化学预防剂，预防DMBA诱导的大鼠乳腺肿瘤发生和乳腺加合物形成。
