Appel M J, van Garderen-Hoetmer A, Woutersen R A
Department of Pathology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands.
Cancer Lett. 1996 Jun 5;103(2):157-62. doi: 10.1016/0304-3835(96)04207-3.
The effects of vitamins E and E, beta-carotene and selenium on development of N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic tumours in hamsters were investigated. Dietary supplementation of vitamin C, alone as well as in combination with beta-carotene resulted in consistently lower numbers of advanced ductular lesions. The differences with the controls, however, did not reach the level of statistical significance. Beta-Carotene alone demonstrated no inhibitory effect on the development of (pre)neoplastic lesions in the pancreas. Vitamin E or Se, either alone or in combination, had no effect on the development of advanced ductular lesions in BOP-treated hamsters.
研究了维生素E、β-胡萝卜素和硒对N-亚硝基双（2-氧代丙基）胺（BOP）诱导的仓鼠胰腺肿瘤发生发展的影响。膳食补充维生素C，单独补充以及与β-胡萝卜素联合补充，均使晚期导管病变的数量持续减少。然而，与对照组的差异未达到统计学显著水平。单独使用β-胡萝卜素对胰腺（癌前）病变的发生发展没有抑制作用。维生素E或硒单独使用或联合使用，对BOP处理的仓鼠晚期导管病变的发生发展均无影响。
