伴刀豆球蛋白A对小鼠迟发型超敏反应诱导的抑制作用：针对绵羊红细胞。

Suppression of delayed type hypersensitivity induction to sheep red blood cells by concanavalin A in mice.

作者信息

Machida A, Yasuda S, Kumazawa Y, Mizunoe K

出版信息

Int Arch Allergy Appl Immunol. 1977;54(2):158-64. doi: 10.1159/000231819.

Abstract

An examination was carried out on the in vivo effect of concanavalin A (Con A) on the induction of delayed-type hypersensitivity (DTH) to heterologous erythrocytes in mice. DTH induction was suppressed by an intravenous injection of 100 microng of Con A 1 day before, or simultaneously with immunization. This suppression was mediated by Con-A-activated spleen cells, and also by their cell-free extracts. However, this suppressive effect was abrogated by absorption of cell-free extracts with immunoadsorbent composed of rabbit anti-mouse thymocyte serum (ATS), indicating that suppressive factors for DTH induction make up one of the components extractable from Con-A-activated T cell population.

摘要

对伴刀豆球蛋白A（Con A）在小鼠体内对异源红细胞迟发型超敏反应（DTH）诱导的影响进行了研究。在免疫前1天或同时静脉注射100微克Con A可抑制DTH诱导。这种抑制作用由Con A激活的脾细胞介导，也由其无细胞提取物介导。然而，用兔抗小鼠胸腺细胞血清（ATS）组成的免疫吸附剂吸收无细胞提取物可消除这种抑制作用，这表明DTH诱导的抑制因子是可从Con A激活的T细胞群体中提取的成分之一。