Coffey L L, Reith M E, Chen N H, Mishra P K, Jobe P C
Department of Biomedical and Therapeutic Sciences (Formerly Basic Sciences), University of Illinois College of Medicine, Peoria 61656, USA.
Epilepsia. 1996 Feb;37(2):188-97. doi: 10.1111/j.1528-1157.1996.tb00011.x.
Forebrain seizures were kindled in rats by daily electrical stimulation of the amygdala. Genetically epilepsy-prone rats scoring 9 (GEPR-9s) on the seizure severity scale during audiogenic seizure (AGS) screening ("brainstem seizure-experienced") required fewer stimulations to achieve fully kindled seizures (forelimb clonus with rearing and falling) than control rats. AGS-naive GEPR-9s required an intermediate number of stimulations, indicating a role for both genetic predisposition and previous acoustically evoked brainstem seizure experience. Other forebrain kindling indices such as afterdischarge threshold/duration and seizure latency/duration also involved genetic as well as phenotypic (previous seizure experience) factors. In most GEPR-9s in both groups, severe brainstem seizures occurred after forebrain stimulation. The occurrence of brainstem seizures had a random nature and was not related to the sequence of kindling-dependent forebrain seizure progression. The lack of a difference in the occurrence of brainstem seizures between seizure-experienced and AGS-naive GEPR-9s suggest that genetic predisposition is the major factor in forebrain seizure-induced activation of brainstem seizure circuitry. This brainstem seizure activity appears to model pertinent aspects of secondary generalization observed in human partial seizures.
通过每日对大鼠杏仁核进行电刺激来引发前脑癫痫发作。在听源性癫痫发作（AGS）筛查（“经历过脑干癫痫发作”）期间，癫痫发作严重程度评分为9的遗传性癫痫易感大鼠（GEPR-9s）比对照大鼠需要更少的刺激次数就能达到完全点燃的癫痫发作（伴有站立和跌倒的前肢阵挛）。未经历过AGS的GEPR-9s需要中等数量的刺激次数，这表明遗传易感性和先前由声音诱发的脑干癫痫发作经历都起作用。其他前脑点燃指标，如后放电阈值/持续时间和癫痫发作潜伏期/持续时间，也涉及遗传因素以及表型（先前的癫痫发作经历）因素。在两组中的大多数GEPR-9s中，前脑刺激后会出现严重的脑干癫痫发作。脑干癫痫发作的发生具有随机性，且与依赖于点燃的前脑癫痫发作进展顺序无关。经历过癫痫发作的GEPR-9s和未经历过AGS的GEPR-9s在脑干癫痫发作发生率上没有差异，这表明遗传易感性是前脑癫痫发作诱发脑干癫痫发作回路激活的主要因素。这种脑干癫痫发作活动似乎模拟了在人类部分性癫痫中观察到的继发性泛化的相关方面。
