Gilles R, Thiollier S, Guinebretière J M, Petit J Y, Contesso G, Rochard F, Tardivon A A, Bittoun J, Arriagada R, Vanel D
Service de Radiologie, Institut Gustave Roussy, Villejuif.
J Gynecol Obstet Biol Reprod (Paris). 1995;24(8):788-93.
The aim of this study is to determine the diagnostic value of magnetic resonance imaging in the diagnosis of local recurrence of breast cancer. From 1991 to 1994, 61 women were studied prospectively using magnetic resonance imaging. All examinations were made on a 1.5 Testa machine with T1 weighted images and after gadolium-dota injection and dynamic images (T1 weighted sequences every 47 seconds during injection of a gadolinium-dota bolus). All the pre-injection, images in the dynamic series were subtracted from the images after injection. A surgical biopsy was obtained in 39 patients yielding a diagnosis of local recurrence (n = 28) or a benign lesion (n = 11). Among the 28 local recurrences, pathology examination reported invasive cancer in 22 and intra-ductal carcinoma in 6. In 22 patients with normal magnetic resonance imaging, follow-up examinations were performed every 6 months. There were no local recurrences within a delay of 6 to 36 months. Twenty-six of the 28 patients with a local recurrence, cystosteatonecrosis and surgery scar tissue less than 6 months old showed contrast uptake 1 min and 34 s after gadolinium injection during the dynamic sequence. This product uptake yielded nodular images within the invasive carcinomas and linear images in the intraductal cancers. In all cases, it is easier to visualize this contrast uptake in subtraction images. In conclusion, magnetic resonance imaging is a simple reliable method for the diagnosis of local recurrence of breast cancer.
本研究的目的是确定磁共振成像在乳腺癌局部复发诊断中的价值。1991年至1994年,对61名女性进行了磁共振成像前瞻性研究。所有检查均在1.5特斯拉机器上进行,采用T1加权图像,注射钆喷酸葡胺后进行动态成像(注射钆喷酸葡胺团注期间每47秒采集一次T1加权序列)。将动态系列中所有注射前图像与注射后图像相减。39例患者进行了手术活检,诊断为局部复发(n = 28)或良性病变(n = 11)。在28例局部复发患者中,病理检查报告浸润性癌22例,导管内癌6例。22例磁共振成像正常的患者每6个月进行一次随访检查。在6至36个月的时间内未出现局部复发。28例局部复发、囊肿性脂肪坏死和手术瘢痕组织小于6个月的患者中,26例在动态序列中钆注射后1分34秒显示对比剂摄取。这种对比剂摄取在浸润性癌中产生结节状图像,在导管内癌中产生线性图像。在所有情况下,在减影图像中更容易观察到这种对比剂摄取。总之,磁共振成像是诊断乳腺癌局部复发的一种简单可靠的方法。