细胞固定钙在化合物48/80释放组胺中的作用。
The role of cell-fixed calcium in histamine release by compound 48/80.
作者信息
Garland L G, Payne A N
出版信息
Br J Pharmacol. 1979 Apr;65(4):609-13. doi: 10.1111/j.1476-5381.1979.tb07871.x.
Abstract
- Histamine release by compound 48/80 was substantially reduced in a time-dependent manner (maximum at 30 min) by pre-incubating mast cells in calcium-free medium at 37 degrees C but not at 2 degrees C. This effect was optimal at pH 7.0 to 7.5. 2. The re-introduction of calcium (0.1 to 3 mmol/l) restored histamine release to the control value; this effect was independent of temperature. 3. Strontium (1 to 30 mmol/l) partially reversed the effect of calcium deprivation but the same concentrations of barium and magnesium depressed histamine release even further. Magnesium (3 to 15 mmol/l) antagonized the effect of calcium replacement. 4. Results suggest that the level of cell-fixed calcium involved in compound 48/80-induced histamine release may be controlled by the combination of rapid passive influx and slow active efflux.
摘要
- 通过在37℃无钙培养基中预孵育肥大细胞，化合物48/80诱导的组胺释放以时间依赖性方式大幅降低（30分钟时达到最大值），但在2℃时则不然。此效应在pH 7.0至7.5时最为显著。2. 重新引入钙（0.1至3 mmol/L）可使组胺释放恢复至对照值；此效应与温度无关。3. 锶（1至30 mmol/L）部分逆转了钙剥夺的效应，但相同浓度的钡和镁进一步抑制了组胺释放。镁（3至15 mmol/L）拮抗了钙替代的效应。4. 结果表明，参与化合物48/80诱导组胺释放的细胞固定钙水平可能由快速被动内流和缓慢主动外流的组合控制。
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