Chance W T, Zhang X, Balasubramaniam A, Fischer J E
Veterans Affairs Medical Center, Cincinnati, OH, USA.
Life Sci. 1996;58(21):1785-94. doi: 10.1016/0024-3205(96)00162-2.
Maintaining rats on TPN for 7 days was associated with a 50% reduction in gut mass and protein content. Co-infusing PYY with total parenteral nutrition (TPN) resulted in significant savings in jejunal wet mass and elevated protein content of jejunum, ileum and colon as compared with rats maintained on TPN alone. No significant effects of PYY on plasma amino acid profile were noted. Although minor alterations in mucosal polyamines were observed in rats maintained on TPN, co-infusion of PYY had no significant effect on gut polyamine concentrations. These results suggest that PYY has trophic effects upon the gut during otherwise catabolic conditions. Therefore, co-infusion of PYY with TPN may suggest methods whereby loss of intestinal mucosa and atrophy-associated complications of TPN may be modulated.
让大鼠接受7天的全胃肠外营养（TPN），会使其肠道质量和蛋白质含量降低50%。与仅接受TPN的大鼠相比，将肽YY（PYY）与全胃肠外营养共同输注，可显著减少空肠湿重，并提高空肠、回肠和结肠的蛋白质含量。未观察到PYY对血浆氨基酸谱有显著影响。虽然接受TPN的大鼠的黏膜多胺有轻微改变，但PYY的共同输注对肠道多胺浓度无显著影响。这些结果表明，在分解代谢状态下，PYY对肠道有营养作用。因此，将PYY与TPN共同输注可能提示了一些方法，借此可调节TPN相关的肠黏膜丧失和萎缩相关并发症。
