Chance W T, Zhang X, Zuo L, Balasubramaniam A
Department of Surgery, University of Cincinnati Medical Center, Ohio 45267-0558, USA.
Nutrition. 1998 Jun;14(6):502-7. doi: 10.1016/s0899-9007(98)00038-0.
Prevention of gut hypoplasia associated with total parenteral nutrition (TPN) was investigated in 67 adult male Fisher 344 rats. Mass and protein content of the small intestine was reduced by 31% and 39%, respectively, after 7 d of TPN in tumor-bearing (TB) rats. Coinfusing peptide YY (PYY; 1 nmol.kg-1.h-1) and treating the rats with the anabolic beta-adrenergic agonist, clenbuterol (CLE; 2 mg.kg-1.d-1), resulted in significant savings in small intestine weight (26% increase) and protein (42% increase). Although the colon also exhibited a significant decrease in mass (31%), none of the treatment combinations were effective in this region of the gut. Histologic analysis of ileum suggested that the additive effects of PYY and CLE were due to differential effects of these compounds on mucosal and muscular tissues, respectively. This combination of treatments also resulted in significant savings (30% increase) in gastrocnemius protein, suggesting a reduction in the cachectic response. These results suggest that TPN-induced gut hypoplasia and cancer cachexia may be reduced by the proper combination of nutritional, hormonal, and pharmacologic treatments. In addition, the anabolic effects of various treatments may be additive to counteract TPN-induced gut atrophy.
在67只成年雄性Fisher 344大鼠中研究了预防与全胃肠外营养（TPN）相关的肠道发育不全的情况。荷瘤（TB）大鼠接受TPN 7天后，小肠的质量和蛋白质含量分别降低了31%和39%。联合输注肽YY（PYY；1 nmol·kg⁻¹·h⁻¹）并给大鼠使用合成代谢的β-肾上腺素能激动剂克伦特罗（CLE；2 mg·kg⁻¹·d⁻¹），可显著增加小肠重量（增加26%）和蛋白质含量（增加42%）。尽管结肠质量也显著下降（31%），但没有一种治疗组合对肠道的这一区域有效。回肠的组织学分析表明PYY和CLE的相加作用分别是由于这些化合物对黏膜组织和肌肉组织的不同作用。这种治疗组合还使腓肠肌蛋白质显著增加（增加30%），表明恶病质反应有所减轻。这些结果表明，通过适当组合营养、激素和药物治疗，可能减轻TPN诱导的肠道发育不全和癌症恶病质。此外，各种治疗的合成代谢作用可能具有相加性，以抵消TPN诱导的肠道萎缩。
