淋巴毒素和I型肿瘤坏死因子受体在生发中心形成中的作用。
Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers.
作者信息
Matsumoto M, Mariathasan S, Nahm M H, Baranyay F, Peschon J J, Chaplin D D
机构信息
Center for Immunology and Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Science. 1996 Mar 1;271(5253):1289-91. doi: 10.1126/science.271.5253.1289.
In mice deficient in either lymphotoxin-alpha (LT-alpha) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow.
在缺乏淋巴毒素α（LT-α）或I型肿瘤坏死因子（TNF）受体，但不缺乏II型TNF受体的小鼠中，外周淋巴器官无法形成生发中心。通过移植正常骨髓，LT-α缺陷小鼠的生发中心形成得以恢复，这表明建立这种淋巴结构所需的表达LT-α的细胞来源于骨髓。
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