Soto-Ramirez L E, Renjifo B, McLane M F, Marlink R, O'Hara C, Sutthent R, Wasi C, Vithayasai P, Vithayasai V, Apichartpiyakul C, Auewarakul P, Peña Cruz V, Chui D S, Osathanondh R, Mayer K, Lee T H, Essex M
Harvard AIDS Institute, Boston, MA 02115, USA.
Science. 1996 Mar 1;271(5253):1291-3. doi: 10.1126/science.271.5253.1291.
Heterosexual transmission by vaginal intercourse accounts for most transmission of human immunodeficiency virus-type 1 (HIV-1) in Africa and Asia but is less important in the HIV-1 epidemics of the United States and Western Europe. Epithelial Langerhans' cells (LCs) represent a possible source of initial cell contact for vaginal infection. Fifteen primary isolates of HIV-1 from U.S. homosexuals and 18 HIV-1 isolates from Thailand heterosexuals were evaluated for growth in LCs of U.S. origin. All the viruses from the Thai heterosexuals, which were subtype E, grew more efficiently in the LCs than any of the viruses from the U.S. homosexuals, which are subtype B. These results suggest that LC tropism is associated with the efficiency of heterosexual transmission of HIV.
在非洲和亚洲，通过阴道性交的异性传播占人类免疫缺陷病毒1型（HIV-1）传播的大部分，但在美国和西欧的HIV-1流行中则不那么重要。上皮朗格汉斯细胞（LCs）是阴道感染初始细胞接触的一个可能来源。对来自美国同性恋者的15株HIV-1原代分离株和来自泰国异性恋者的18株HIV-1分离株进行了在美国来源的LCs中生长情况的评估。来自泰国异性恋者的所有病毒均为E亚型，在LCs中的生长效率高于来自美国同性恋者的任何病毒，后者为B亚型。这些结果表明，LC嗜性与HIV异性传播的效率相关。
