Mellors J W, Rinaldo C R, Gupta P, White R M, Todd J A, Kingsley L A
Department of Medicine, School of Medicine, University of Pittsburgh 15213, USA.
Science. 1996 May 24;272(5265):1167-70. doi: 10.1126/science.272.5265.1167.
The relation between viremia and clinical outcome in individuals infected with human immunodeficiency virus-type 1 (HIV-1) has important implications for therapeutic research and clinical care. HIV-1 RNA in plasma was quantified with a branched-DNA signal amplification assay as a measure of viral load in a cohort of 180 seropositive men studied for more than 10 years. The risk of acquired immunodeficiency syndrome (AIDS) and death in study subjects, including those with normal numbers of CD4+ T cells, was directly related to plasma viral load at study entry. Plasma viral load was a better predictor of progression to AIDS and death than was the number of CD4+ T cells.
1型人类免疫缺陷病毒（HIV-1）感染者的病毒血症与临床结局之间的关系对治疗研究和临床护理具有重要意义。在一项对180名血清阳性男性进行了超过10年研究的队列中，采用分支DNA信号扩增测定法对血浆中的HIV-1 RNA进行定量，以此作为病毒载量的指标。研究对象（包括CD4+T细胞数量正常者）发生获得性免疫缺陷综合征（AIDS）和死亡的风险与研究开始时的血浆病毒载量直接相关。与CD4+T细胞数量相比，血浆病毒载量是AIDS进展和死亡的更好预测指标。
