Novelli M R, Williamson J A, Tomlinson I P, Elia G, Hodgson S V, Talbot I C, Bodmer W F, Wright N A
Cancer Genetics Laboratory, Imperial Cancer Research Fund (ICRF) Laboratories, London, UK.
Science. 1996 May 24;272(5265):1187-90. doi: 10.1126/science.272.5265.1187.
It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.
肿瘤起源于单一细胞及其后代的一个或一系列突变，这一观点已被广泛接受。通过用Y染色体探针进行原位杂交，直接检测了一名患有家族性腺瘤性息肉病（FAP）的XO/XY嵌合体个体的结肠腺瘤和未受累肠黏膜的克隆起源。在该患者中，小肠和大肠的隐窝是克隆性的，但至少76%的微腺瘤起源于多克隆。
