Bormann J, Feigenspan A
Max-Planck-Institut für Hirnforschung, Frankfurt, Germany.
Trends Neurosci. 1995 Dec;18(12):515-9. doi: 10.1016/0166-2236(95)98370-e.
gamma-Aminobutyric acid (GABA) is an important neurotransmitter that mediates inhibition in the vertebrate CNS. Until recently, two receptor subtypes were known: bicuculline-sensitive GABAA and baclofen-sensitive GABAB receptors. Several lines of evidence now indicate the existence of a third class of GABA receptor, which is distinct pharmacologically from GABAA and GABAB receptors and is found predominantly in the vertebrate retina. These novel GABAC receptors are Cl- pores. They are insensitive to drugs that modulate GABAA and GABAB receptors and are activated selectively by cis-4-aminoacrotonic acid.
γ-氨基丁酸（GABA）是一种重要的神经递质，在脊椎动物中枢神经系统中介导抑制作用。直到最近，已知有两种受体亚型：荷包牡丹碱敏感的GABAA受体和巴氯芬敏感的GABAB受体。现在有几条证据表明存在第三类GABA受体，其在药理学上与GABAA和GABAB受体不同，主要存在于脊椎动物视网膜中。这些新型GABAC受体是氯离子通道。它们对调节GABAA和GABAB受体的药物不敏感，并被顺式-4-氨基巴豆酸选择性激活。
