Walsh J W, Hasler W L, Nugent C E, Owyang C
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0362, USA.
Am J Physiol. 1996 Mar;270(3 Pt 1):G506-14. doi: 10.1152/ajpgi.1996.270.3.G506.
Women in pregnancy experience nausea, which correlates with gastric slow-wave rhythm disruption. Mediators of these dysrhythmias were explored. To quantitate slow-wave disruption, eight pregnant women with first-trimester nausea underwent electrogastrography after a 250-kcal meal. Results were compared with nonpregnant women with nausea during a prior pregnancy who received estradiol and/or progesterone to levels of the first trimester of pregnancy. Five pregnant women exhibited dysrhythmias, with increases in combined recording time in tachygastria plus bradygastria, as well as decreases in the percentage of electrogastrography signal power in the normal 3 cycle/min range (cpm), compared with nonpregnant women (P<0.05). Estradiol did not evoke dysrhythmias in nonpregnant women; however, progesterone induced increases in recording time in bradygastria plus tachygastria and increases in bradygastric signal power with corresponding decreases in signal power in the 3-cpm range (P<0.05). With estradiol and progesterone coadministration, an additive effect was observed at 3.3 +/- 0.8 h, with increased recording time in bradygastria alone and in bradygastria plus tachygastria with corresponding increases in bradygastric signal power and decreases in power in the 3-cpm range (P<0.05). In conclusion, women with nausea of pregnancy exhibit slow-wave rhythm disruption. Similar dysrhythmias are evoked in nonpregnant women by progesterone alone or in combination with estradiol in doses that reproduce levels in pregnancy. Thus gastric dysrhythmias in pregnancy may be due to a combination of elevated progesterone and estrogen levels.
孕期女性会出现恶心症状，这与胃慢波节律紊乱有关。对这些心律失常的介导因素进行了探究。为了量化慢波紊乱情况，八名孕早期有恶心症状的孕妇在进食250千卡食物后接受了胃电图检查。将结果与之前怀孕时有恶心症状且接受雌二醇和/或孕酮治疗使激素水平达到孕早期水平的非孕期女性进行比较。与非孕期女性相比，五名孕妇出现了心律失常，胃动过速加胃动过缓的联合记录时间增加，正常3次/分钟范围（cpm）内胃电图信号功率百分比降低（P<0.05）。雌二醇未在非孕期女性中诱发心律失常；然而，孕酮导致胃动过缓加胃动过速的记录时间增加，胃动过缓信号功率增加，同时3-cpm范围内的信号功率相应降低（P<0.05）。同时给予雌二醇和孕酮时，在3.3±0.8小时观察到相加效应，仅胃动过缓以及胃动过缓加胃动过速的记录时间增加，胃动过缓信号功率相应增加，3-cpm范围内的功率降低（P<0.05）。总之，孕期恶心的女性存在慢波节律紊乱。单独使用孕酮或与雌二醇联合使用并使剂量达到孕期水平时，会在非孕期女性中诱发类似的心律失常。因此，孕期胃节律紊乱可能是由于孕酮和雌激素水平升高共同作用所致。
