Maile S, Merker H J
Institute of Anatomy, Free University of Berlin, Germany.
Ann Anat. 1996 Apr;178(2):159-67. doi: 10.1016/S0940-9602(96)80036-7.
The localization and fine structure of C-cells of the thyroid glands from 31 marmosets (Callithrix jacchus) of different age groups (newborn to 11 years old) were investigated by electron microscopy and immunomorphology (APAAP, calcitonin). Calcitonin-positive cells were found concentrated in the middle third of the gland. Their localization in the follicular wall or in the interstitial space could not clearly be demonstrated by light microscopy. In adult animals, they were always located within the basal lamina, as revealed by electron microscopy. In newborn animals, their localization was difficult because of the dense cell packing. The fine structure of the C-cells with their 200 nm electron-dense granules corresponded to that of other species. Two cell types could be distinguished: (1) granule-rich cells in the storing phase and (2) cells with fewer granules and well-developed rough endoplasmic reticulum in the synthesis phase. The concentration of C-cells in the middle third of the marmoset thyroid gland renders this species especially suitable for morphological investigations and in vitro experiments.
通过电子显微镜和免疫形态学（抗碱性磷酸酶桥联酶标法、降钙素）对31只不同年龄组（从新生到11岁）狨猴（Callithrix jacchus）甲状腺C细胞的定位和精细结构进行了研究。发现降钙素阳性细胞集中在腺体的中三分之一处。光镜下无法清楚显示它们在滤泡壁或间质空间中的定位。电子显微镜显示，成年动物中，它们总是位于基膜内。新生动物中，由于细胞密集堆积，其定位较困难。C细胞的精细结构及其200纳米的电子致密颗粒与其他物种的相似。可区分出两种细胞类型：（1）处于储存阶段的富含颗粒的细胞和（2）处于合成阶段颗粒较少且粗面内质网发达的细胞。狨猴甲状腺中三分之一处C细胞的集中使得该物种特别适合进行形态学研究和体外实验。
