Seal E, McDonnell W F, House D E
Human Studies Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.
Arch Environ Health. 1996 Mar-Apr;51(2):132-7. doi: 10.1080/00039896.1996.9936006.
The purpose of this study was to investigate the effects of age, socioeconomic status, and menstrual cycle phase on the pulmonary response to ozone exposure. Three hundred seventy-two healthy white and black young adults, between the ages of 18 and 35 y, were exposed only once to 0.0, 0.12, 0.18, 0.24, 0.30, or 0.40 ppm ozone for 2.3 h. Prior to and after exposure, pulmonary function tests were obtained. Prior to exposure, each subject completed a personal and family-history questionnaire. The responses to this questionnaire were used to investigate age, socioeconomic status, and menstrual cycle phase effects on pulmonary responsiveness to ozone. We concluded that the ages of subjects, within the age range studied, had an effect on responsiveness (i.e., decrements in forced expiratory volume in 1 s decreased as the subjects' ages decreased). Socioeconomic status, as reflected by education of fathers, also appeared to affect forced expiratory volume in 1-s responsiveness to ozone, with the middle socioeconomic group being the most responsive. The phase of menstrual cycle did not have an impact on individual responsiveness to ozone.
本研究的目的是调查年龄、社会经济地位和月经周期阶段对肺部对臭氧暴露反应的影响。372名年龄在18至35岁之间的健康白人和黑人青年成年人仅一次暴露于0.0、0.12、0.18、0.24、0.30或0.40 ppm的臭氧中2.3小时。在暴露前后，进行了肺功能测试。在暴露前，每个受试者完成了一份个人和家族病史问卷。对该问卷的回答用于调查年龄、社会经济地位和月经周期阶段对肺部对臭氧反应性的影响。我们得出结论，在所研究的年龄范围内，受试者的年龄对反应性有影响（即，随着受试者年龄的降低，1秒用力呼气量的下降减少）。父亲的教育程度所反映的社会经济地位似乎也影响1秒用力呼气量对臭氧的反应性，中等社会经济群体反应性最强。月经周期阶段对个体对臭氧的反应性没有影响。
