阿尔茨海默病患者脑脊液中可溶性β淀粉样蛋白和载脂蛋白E的浓度：与脑内淀粉样蛋白负荷的相关性
Cerebrospinal fluid concentrations of soluble amyloid beta-protein and apolipoprotein E in patients with Alzheimer's disease: correlations with amyloid load in the brain.
作者信息
Pirttilä T, Mehta P D, Soininen H, Kim K S, Heinonen O, Paljärvi L, Kosunen O, Riekkinen P, Wisniewski H M
机构信息
Department of Immunology, Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.
出版信息
Arch Neurol. 1996 Feb;53(2):189-93. doi: 10.1001/archneur.1996.00550020105022.
OBJECTIVE
To compare soluble amyloid beta-protein and apolipoprotein E levels in cerebrospinal fluid (CSF) and brain extracts from patients with definite Alzheimer's disease.
SETTING
University medical center.
PATIENTS
Nineteen patients with definite Alzheimer's disease.
MAIN OUTCOME MEASURES
Soluble amyloid beta-protein and apolipoprotein E levels in CSF, in neutral and low-pH brain extracts, and in formic acid-treated sections of the frontal, temporal, and cerebellar cortices, measured using enzyme-linked immunosorbent assay.
RESULTS
Soluble amyloid beta-protein and apolipoprotein E levels in CSF were significantly lower in patients with congophilic angiopathy than in those without angiopathy. The levels did not correlate with the number of amyloid plaques in the neocortex. There was, however, a tendency toward an inverse correlation between the amount of amyloid beta-protein in the frontal cortex extracts and the soluble amyloid beta-protein level in CSF.
CONCLUSION
Soluble amyloid beta-protein levels in CSF may reflect amyloid accumulation in brain blood vessels.
目的
比较确诊为阿尔茨海默病患者脑脊液（CSF）及脑提取物中可溶性β淀粉样蛋白和载脂蛋白E水平。
地点
大学医学中心。
患者
19例确诊为阿尔茨海默病的患者。
主要观察指标
采用酶联免疫吸附测定法测量CSF、中性和低pH值脑提取物以及额叶、颞叶和小脑皮质甲酸处理切片中的可溶性β淀粉样蛋白和载脂蛋白E水平。
结果
嗜刚果红血管病变患者CSF中的可溶性β淀粉样蛋白和载脂蛋白E水平显著低于无血管病变患者。这些水平与新皮质中淀粉样斑块数量无关。然而，额叶皮质提取物中β淀粉样蛋白量与CSF中可溶性β淀粉样蛋白水平之间存在负相关趋势。
结论
CSF中可溶性β淀粉样蛋白水平可能反映脑血中淀粉样蛋白的积累。
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