Endo E G, Walton D S, Albert D M
Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, USA.
Arch Ophthalmol. 1996 Jun;114(6):757-61. doi: 10.1001/archopht.1996.01100130749023.
A newborn boy was diagnosed with hepatoblastoma after a systemic workup was prompted because of abnormal-appearing eyes. Radiological examination revealed mass lesions involving the liver, brain, eyes, and ribs. A liver biopsy was performed before death and results showed hepatoblastoma, an unusual solid tumor of childhood. At autopsy, hepatoblastoma was also found histopathologically in the irides and choroid of both eyes. No previous report of hepatoblastoma metastatic to the eye could be found in the medical literature. In addition, we believe this is the first report in a child of a solid tumor metastatic to the choroid and iris, and of a solid tumor metastatic to the iris that is confirmed histopathologically.
一名男婴因眼睛外观异常而接受全面检查后被诊断为肝母细胞瘤。放射学检查发现肝脏、脑、眼和肋骨有肿块病变。在其死亡前进行了肝脏活检，结果显示为肝母细胞瘤，这是一种儿童期罕见的实体瘤。尸检时，在双眼的虹膜和脉络膜中也发现了组织病理学上的肝母细胞瘤。医学文献中未发现肝母细胞瘤转移至眼部的既往报道。此外，我们认为这是首次报道儿童实体瘤转移至脉络膜和虹膜，以及首次报道经组织病理学证实的实体瘤转移至虹膜。
