Begemann Martin, Trippett Tanya M, Lis Eric, Antunes Nuno L
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York City, New York 10021, USA.
Pediatr Neurol. 2004 Apr;30(4):295-7. doi: 10.1016/j.pediatrneurol.2003.10.014.
Brain metastases from hepatoblastomas are rare. We report a 2-year-old male who developed multiple hemorrhagic intracranial metastases. Previous reports indicate that brain metastases are an almost uniformly fatal complication of hepatoblastoma, although one long-term survivor has been described. In a child with known hepatoblastoma, the development of neurologic signs or symptoms should lead to the performance of a brain imaging study to exclude the possibility of intracranial extension of the disease.
肝母细胞瘤脑转移罕见。我们报告一名2岁男性患儿，发生了多发性颅内出血性转移瘤。既往报道表明，脑转移是肝母细胞瘤几乎一致的致命并发症，不过曾有1例长期存活者的报道。对于已知患有肝母细胞瘤的儿童，出现神经体征或症状时应进行脑部影像学检查，以排除疾病颅内播散的可能性。
