Krown S E
Clinical Immunology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Cancer Chemother Biol Response Modif. 1996;16:441-61.
Although currently diagnosed in about 40% of HIV-infected individuals at some point in their clinical course, AIDS-associated malignancies may increase in frequency as survival is prolonged and, particularly, as greater numbers of HIV infections occur in women. Although this review has been devoted to AIDS-defining cancers, there are suggestions from epidemiological studies that some of the more common cancers in the general population are beginning to be diagnosed at increased rates in HIV-infected people [141]. In addition, as children born with HIV infection show longer survival, increased cancer rates may be seen in this group as well. While recent advances have been made in understanding the pathogenesis of AIDS-associated malignancies, particularly KS, and modest therapeutic advances have been made, optimal therapy has yet to be defined for any of these neoplasms.
尽管目前在约40%的HIV感染者临床病程中的某个阶段会被诊断出患有艾滋病相关恶性肿瘤，但随着生存期延长，尤其是女性HIV感染人数增多，艾滋病相关恶性肿瘤的发病率可能会上升。尽管本综述聚焦于艾滋病定义性癌症，但流行病学研究表明，普通人群中一些较常见的癌症在HIV感染者中的诊断率开始上升[141]。此外，随着出生时即感染HIV的儿童生存期延长，该群体中的癌症发病率可能也会上升。虽然在理解艾滋病相关恶性肿瘤（尤其是卡波西肉瘤）的发病机制方面取得了最新进展，并且在治疗上也有一定进展，但对于这些肿瘤中的任何一种，最佳治疗方案仍未确定。
