Romito A, Grizzuti M A, Tucci M, Silvestris F
Dipartimento di Scienze Biomediche e Oncologia Umana, Università, Bari.
Recenti Prog Med. 1997 Jul-Aug;88(7-8):348-55.
During the past few years the neoplasms defining the diagnosis of AIDS are in apparent evolution and a new distribution of specific tumors is currently reported in the literature. Besides the Kaposi's sarcoma, non-Hodgkin's lymphomas, and uterine cervical carcinoma, other malignancies are frequently diagnosed in HIV+ population, particularly during the advanced stages of the infection. The pathogenesis of such an increase of tumor diffusion is apparently related to the persistence of several herpes viruses including HHV8 and HPV whose molecular interaction with HIV may contribute to the genetic variations suitable for tumor development. The epidermoid anal carcinoma is a tumor whose appearance is increasingly recurrent in HIV+ patients, although it is not considered as an AIDS-defining neoplasia. This tumor is prevalent in HIV+ homosexual men, in particular during the full-blown immunodeficiency disease. Here we report the case of a patient whose diagnosis of AIDS was emphasized by the concurrent presence of the anal tumor.
在过去几年中，用于定义艾滋病诊断的肿瘤呈现出明显的演变，目前文献报道了特定肿瘤的新分布情况。除了卡波西肉瘤、非霍奇金淋巴瘤和子宫颈癌外，其他恶性肿瘤在HIV阳性人群中也经常被诊断出来，尤其是在感染的晚期阶段。肿瘤扩散增加的发病机制显然与包括HHV8和HPV在内的几种疱疹病毒的持续存在有关，它们与HIV的分子相互作用可能导致适合肿瘤发展的基因变异。表皮样肛管癌是一种在HIV阳性患者中越来越常见的肿瘤，尽管它不被视为艾滋病定义性肿瘤。这种肿瘤在HIV阳性的同性恋男性中尤为普遍，特别是在艾滋病全面发作期。在此，我们报告一例患者，其同时患有肛管肿瘤，从而确诊为艾滋病。
