Wada R, Hyon S H, Ikada Y
Research Center for Biomedical Engineering, Kyoto University, Japan.
J Biomater Sci Polym Ed. 1996;7(8):715-25. doi: 10.1163/156856296x00480.
Tartaric acid, malic acid, and glyceric acid were copolycondensed with glycolic acid at various molar ratios in feed to quickly synthesize biodegradable oligoesters. They were likely to have a moderately cross-linked structure with relatively low molecular weights and hydrophilic groups on the chains. In addition to macroscopic gels which were insoluble in any solvents, we could obtain the oligoesters which were insoluble in water but soluble in N,N-dimethylformamide. The degradation rate of the oligoesters was higher than that of lactic acid (LA) oligomers having molecular weights of a few thousands. On the contrary, their glass transition and flow temperatures were much higher than those of LA oligomers, indicating that their handling during the preparation of drug delivery dosage forms was much improved. The formulation of microspheres containing drugs from the oligoesters revealed that they were useful as biodegradable matrices having high degradation rates.
酒石酸、苹果酸和甘油酸与乙醇酸按进料中的各种摩尔比进行共缩聚反应，以快速合成可生物降解的低聚酯。它们可能具有适度交联的结构，分子量相对较低，且链上带有亲水性基团。除了在任何溶剂中都不溶的宏观凝胶外，我们还能得到不溶于水但可溶于N，N - 二甲基甲酰胺的低聚酯。这些低聚酯的降解速率高于分子量为数千的乳酸（LA）低聚物。相反，它们的玻璃化转变温度和流动温度比LA低聚物高得多，这表明在制备药物递送剂型过程中它们的加工性能有了很大改善。含药物的低聚酯微球制剂表明，它们可用作具有高降解速率的可生物降解基质。
