色胺中TMS基团的选择性引入：色胺N1-TMS衍生物的制备。
Selective introduction of TMS groups in tryptamines: preparation of N1-TMS derivatives of tryptamines.
作者信息
Narasimhachari N, Leiner K
出版信息
J Chromatogr Sci. 1977 May 10;15(5):181-4. doi: 10.1093/chromsci/15.5.181.
PMID:863995
Abstract
Indolethylamines (tryptamines) with a primary animofunction react with Regisil under controlled conditions to yield a mono TMS derivative. Mass spectrometry to these derivatives shows that the TMS group is substituted on the indolic nitrogen (N1) and not the primary amino nitrogen. This is confirmed by converting these compounds to their isothiocyanate derivatives. The GC and GC-MS data of some typical compounds are presented.
摘要
具有伯氨基官能团的吲哚乙胺（色胺）在可控条件下与瑞吉硅反应生成单三甲基硅基衍生物。对这些衍生物进行质谱分析表明，三甲基硅基取代在吲哚氮（N1）上，而非伯氨基氮上。将这些化合物转化为异硫氰酸酯衍生物可证实这一点。文中给出了一些典型化合物的气相色谱和气相色谱 - 质谱数据。
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