Miyamoto T, Akashi K, Hayashi S, Gondo H, Murakawa M, Tanimoto K, Harada M, Niho Y
Department of Hematology, Harasanshin General Hospital, Fukuoka, Japan.
Bone Marrow Transplant. 1996 Feb;17(2):185-90.
Soluble interleukin-2 receptors (sIL-2R) are elevated in various disorders involving the activation of T cells. We measured serial serum concentrations of sIL-2R in 30 patients receiving allogeneic BMT to evaluate the usefulness of sIL-2R as a parameter for acute GVHD. In the 17 patients who developed acute GVHD, the sIL-2R concentration rose significantly on day 3 following transplantation, preceding the occurrence of acute GVHD. This change was not seen in the 13 patients without acute GVHD. The serum concentration of sIL-2R decreased as the acute GVHD subsided. The peak concentration of serum sIL-2R correlated with the severity of the acute GVHD. Simultaneous measurement of tumor necrosis factor alpha (TNF alpha) showed a significant rise in patients with acute GVHD, that became evident earlier than the sIL-2R elevation. TNF alpha concentrations also decreased following treatment of the acute GVHD. However, significant rise in TNF alpha were also seen in the early phase of allogeneic BMT in patients who did not develop acute GVHD. Our data suggest that the serum concentrations of sIL-2R as well as TNF alpha might reflect the severity of acute GVHD, and that the serum sIL-2R concentration might be a sensitive and practical indicator for acute GVHD.
可溶性白细胞介素-2受体（sIL-2R）在各种涉及T细胞激活的疾病中都会升高。我们检测了30例接受异基因骨髓移植患者的血清sIL-2R系列浓度，以评估sIL-2R作为急性移植物抗宿主病（GVHD）指标的实用性。在发生急性GVHD的17例患者中，移植后第3天sIL-2R浓度显著升高，早于急性GVHD的发生。在未发生急性GVHD的13例患者中未观察到这种变化。随着急性GVHD的缓解，血清sIL-2R浓度下降。血清sIL-2R的峰值浓度与急性GVHD的严重程度相关。同时检测肿瘤坏死因子α（TNFα）显示，急性GVHD患者的TNFα显著升高，且比sIL-2R升高更早出现。急性GVHD治疗后TNFα浓度也下降。然而，在未发生急性GVHD的患者接受异基因骨髓移植的早期阶段也观察到TNFα显著升高。我们的数据表明，血清sIL-2R以及TNFα浓度可能反映急性GVHD的严重程度，并且血清sIL-2R浓度可能是急性GVHD的一个敏感且实用的指标。
