Seber A, Khan S P, Kersey J H
Bone Marrow Transplantation Program, University of Minnesota, Minneapolis 55455, USA.
Bone Marrow Transplant. 1996 Feb;17(2):207-11.
We evaluated patients presenting with large and recurrent sterile serosal effusions following bone marrow transplants. From a review of the Minnesota BMT Database from 1974 to 1993, seven patients with unexplained multiple effusions involving two or more of the pleural, pericardial or peritoneal cavities were identified. Patients with veno-occlusive disease (VOD), infections, cardiac insufficiency, tumor relapse and GM-CSF toxicity were excluded. All had onset following engraftment and six occurred before day 100. Unexplained multiple effusions were observed in recipients of allogeneic transplants but not autologous transplants and were found only in patients with acute and/or chronic GVHD. Five of seven patients also had cytomegalovirus (CMV) disease. Multiple effusions appear to be part of the presentation of severe acute or chronic GVHD, often in association with CMV disease in patients who receive allogeneic donor marrow.
我们评估了骨髓移植后出现大量复发性无菌性浆膜腔积液的患者。通过回顾1974年至1993年的明尼苏达骨髓移植数据库，确定了7例原因不明的多发性积液患者，积液累及两个或更多的胸膜腔、心包腔或腹膜腔。排除了患有静脉闭塞性疾病（VOD）、感染、心功能不全、肿瘤复发和粒细胞巨噬细胞集落刺激因子（GM-CSF）毒性的患者。所有患者均在植入后发病，6例发生在第100天之前。在异基因移植受者中观察到原因不明的多发性积液，而自体移植受者中未观察到，且仅在急性和/或慢性移植物抗宿主病（GVHD）患者中发现。7例患者中有5例还患有巨细胞病毒（CMV）疾病。多发性积液似乎是严重急性或慢性GVHD表现的一部分，在接受异基因供体骨髓的患者中常与CMV疾病相关。
