Melo J A, Shendure J, Pociask K, Silver L M
Department of Molecular Biology, Princeton University, New Jersey 08544-1014, USA.
Nat Genet. 1996 Jun;13(2):147-53. doi: 10.1038/ng0696-147.
Mice from various inbred strains consume alcoholic beverages at highly reproducible and strain-specific levels. While most mice consume alcohol in moderate amounts, C57BL/6J animals exhibit sustained oral ingestion of high levels of alcohol in the presence of competing water and food. We now report a genetic investigation of this phenotype as one potential model for alcoholism. An intercross-backcross breeding protocol was used to identify two recessive alcohol preference quantitative trait loci (QTLs) that are both sex-restricted in expression. A comparison of our results with those of an earlier morphine preference study argues against the hypothesis of a single unified phenotype defined by a preference for all euphoria-producing drugs.
来自各种近交系的小鼠以高度可重复且特定品系的水平饮用酒精饮料。虽然大多数小鼠适量饮酒，但C57BL/6J动物在有竞争的水和食物存在的情况下，会持续口服高水平的酒精。我们现在报告对这种表型进行遗传研究，将其作为酒精中毒的一种潜在模型。采用回交-杂交育种方案来鉴定两个隐性酒精偏好数量性状位点（QTL），这两个位点在表达上都具有性别限制。将我们的结果与早期吗啡偏好研究的结果进行比较，反驳了由对所有产生欣快感药物的偏好所定义的单一统一表型的假设。
