Miyamoto H, Kubota Y, Shuin T, Shiozaki H
Department of Urology, Yokohama City University School of Medicine, Japan.
Cancer Genet Cytogenet. 1996 Jun;88(2):181-3. doi: 10.1016/0165-4608(95)00292-8.
Presented is a rare case of nonfamilial, hormonally nonfunctional adrenocortical carcinoma with synchronous bilateral adrenal involvement. We investigated adrenal and metastatic tumors for loss of heterozygosity affecting four genetic loci containing the tumor suppressor genes p53, RB, DCC, and APC, using polymerase chain reaction and restriction fragment length polymorphism assay. Allelic losses at the p53 and RB loci were detected in all tumor samples, suggesting that the p53 and RB genes are involved in the tumorigenesis of adrenocortical carcinoma.
本文报告一例罕见的非家族性、激素无功能性肾上腺皮质癌，同时累及双侧肾上腺。我们使用聚合酶链反应和限制性片段长度多态性分析，研究肾上腺肿瘤和转移瘤中影响四个包含肿瘤抑制基因p53、RB、DCC和APC的基因座的杂合性缺失情况。在所有肿瘤样本中均检测到p53和RB基因座的等位基因缺失，提示p53和RB基因参与了肾上腺皮质癌的肿瘤发生过程。
