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用槲寄生提取物Iscador预防20-甲基胆蒽诱导的肉瘤

Prevention of 20-methylcholanthrene-induced sarcoma by a mistletoe extract, Iscador.

作者信息

Kuttan G, Menon L G, Kuttan R

机构信息

Amala Cancer Research Centre, Kerala, India.

出版信息

Carcinogenesis. 1996 May;17(5):1107-9. doi: 10.1093/carcin/17.5.1107.

DOI:10.1093/carcin/17.5.1107
PMID:8640920
Abstract

Iscador, an extract from the semi-parasitic plant Viscum album, was found to inhibit 20-methylcholanthrene-induced carcinogenesis in mice. Intraperitoneal administration of Iscador (1 mg/dose) twice weekly for 15 weeks could completely inhibit 20-methylcholanthrene-induced sarcoma in mice and protect these animals from tumour-induced death. Iscador was found to be effective even at lowered doses. After administration of 0.166, 0.0166 and 0.00166 mg/dose 67, 50 and 17% of animals respectively did not develop sarcoma.

摘要

槲寄生提取物(Iscador)是从半寄生植物欧洲槲寄生中提取的,它被发现可抑制小鼠体内由20-甲基胆蒽诱导的致癌作用。每周两次腹腔注射Iscador(1毫克/剂量),持续15周,可完全抑制小鼠体内由20-甲基胆蒽诱导的肉瘤,并保护这些动物免于肿瘤诱导的死亡。Iscador即使在较低剂量下也被发现是有效的。分别给予0.166、0.0166和0.00166毫克/剂量后,分别有67%、50%和17%的动物未发生肉瘤。

相似文献

1
Prevention of 20-methylcholanthrene-induced sarcoma by a mistletoe extract, Iscador.用槲寄生提取物Iscador预防20-甲基胆蒽诱导的肉瘤
Carcinogenesis. 1996 May;17(5):1107-9. doi: 10.1093/carcin/17.5.1107.
2
Anticarcinogenic and antimetastatic activity of Iscador.伊斯卡多的抗癌和抗转移活性。
Anticancer Drugs. 1997 Apr;8 Suppl 1:S15-6. doi: 10.1097/00001813-199704001-00004.
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Use of Iscador, an extract of European mistletoe (Viscum album), in cancer treatment: prospective nonrandomized and randomized matched-pair studies nested within a cohort study.欧洲槲寄生(白果槲寄生)提取物艾斯卡朵用于癌症治疗:一项队列研究中的前瞻性非随机和随机配对研究。
Altern Ther Health Med. 2001 May-Jun;7(3):57-66, 68-72, 74-6 passim.
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Prospective controlled cohort studies on long-term therapy of ovairian cancer patients with mistletoe (Viscum album L.) extracts iscador.关于用槲寄生(欧洲槲寄生)提取物艾斯卡朵对卵巢癌患者进行长期治疗的前瞻性对照队列研究。
Arzneimittelforschung. 2007;57(10):665-78. doi: 10.1055/s-0031-1296666.
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Absence of tumor growth stimulation in a panel of 26 human tumor cell lines by mistletoe (Viscum album L.) extracts Iscador in vitro.槲寄生(欧洲槲寄生)提取物Iscador在体外对26种人类肿瘤细胞系均无肿瘤生长刺激作用。
Arzneimittelforschung. 2006 Jun;56(6A):435-40. doi: 10.1055/s-0031-1296809.
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Inhibitory effects of Ixora javanica extract on skin chemical carcinogenesis in mice and its antitumour activity.龙船花提取物对小鼠皮肤化学致癌作用的抑制效果及其抗肿瘤活性。
Cancer Lett. 1991 Dec 1;60(3):253-8. doi: 10.1016/0304-3835(91)90121-w.
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Viscotoxins, mistletoe lectins and their isoforms in mistletoe (Viscum album L.) extracts Iscador.欧洲槲寄生提取物Iscador中的毒肽、槲寄生凝集素及其亚型
Arzneimittelforschung. 2006 Jun;56(6A):428-34. doi: 10.1055/s-0031-1296808.
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[Iscador--mistletoe extract for cancer treatment. Documentation No. 10].[艾斯卡德——用于癌症治疗的槲寄生提取物。文件编号10]
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Preclinical investigations with mistletoe (Viscum album L.) extract Iscador.用槲寄生(欧洲槲寄生)提取物Iscador进行的临床前研究。
Arzneimittelforschung. 2006 Jun;56(6A):497-507. doi: 10.1055/s-0031-1296817.
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Gene expression profiles of different breast cancer cells compared with their responsiveness to fermented mistletoe (Viscum album L.) extracts Iscador from oak (Quercus), pine (Pinus), white fir (Abies) and apple tree (Malus) in vitro.将不同乳腺癌细胞的基因表达谱与其在体外对来自橡树(栎属)、松树(松属)、白冷杉(冷杉属)和苹果树(苹果属)的发酵槲寄生(欧洲槲寄生)提取物Iscador的反应性进行比较。
Arzneimittelforschung. 2006 Jun;56(6A):483-96. doi: 10.1055/s-0031-1296816.

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