遗传性肝炎和肝癌发生过程中LEC大鼠醛糖还原酶基因表达的诱导。
Induction of aldose reductase gene expression in LEC rats during the development of the hereditary hepatitis and hepatoma.
作者信息
Takahashi M, Hoshi A, Fujii J, Miyoshi E, Kasahara T, Suzuki K, Aozasa K, Taniguchi N
机构信息
Department of Biochemistry, Osaka University Medical School, Japan.
出版信息
Jpn J Cancer Res. 1996 Apr;87(4):337-41. doi: 10.1111/j.1349-7006.1996.tb00227.x.
Abstract
We examined age-related changes in the protein and the mRNA expression of aldose reductase in livers of Long-Evans with a cinnamon-like color (LEC) rats, which develop hereditary hepatitis and hepatoma with aging, using Long-Evans with an agouti color rats as controls. The levels of the protein and mRNA of aldose reductase increased after 20 weeks, at the stage of acute hepatitis, and were maintained at 60 weeks of age, while those of aldehyde reductase seemed to be constant at all ages. The expression of aldose reductase was marked in cancerous lesions in hepatoma-bearing LEC rat liver compared to uninvolved surrounding tissues. These results indicated that elevation of aldose reductase accompanied hepatocarcinogenesis and may be related to the acquisition of immortality of the cancer cells through detoxifying cytotoxic aldehyde compounds.
摘要
我们以具有刺鼠色的Long-Evans大鼠作为对照，研究了肉桂色Long-Evans（LEC）大鼠肝脏中醛糖还原酶的蛋白质和mRNA表达的年龄相关变化。LEC大鼠会随着年龄增长发生遗传性肝炎和肝癌。醛糖还原酶的蛋白质和mRNA水平在20周后，即急性肝炎阶段升高，并在60周龄时维持该水平，而醛脱氢酶的水平在所有年龄段似乎都保持恒定。与未受累的周围组织相比，醛糖还原酶在携带肝癌的LEC大鼠肝脏的癌性病变中表达明显。这些结果表明，醛糖还原酶的升高伴随着肝癌发生，并且可能通过解毒细胞毒性醛化合物与癌细胞的永生性获得有关。
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